I think this could simplify for us.
As an example you might have set your dns for the main domain to your server domain.com and
www.domain.com, while you might have forgoten to set ftp.domain.com, mail.domain.com of servername.domain.com or any domain you want to use only internally but not widely for the web.
The thing we must look at is more the changing protocol, and the impact on dehydrated, as it is still lacking some support (like logging and canceling pending request, which have a limit, while failure in the middle of validation of 80 domains because of one domain will leave these requests pending and next launch will start over, not even trying to fulfill or cancel the previous requests.
Good news with wildcard you will be able to skip hosts list and have a smaller list of domain to include